The next evolutionary step in interventional pulmonology

The new flexible single-use cryoprobes

We are moving forward in interventional pulmonology. Our aim is to improve compatibility and standardization of flexible cryo applications.


Flexible single-use cryoprobes

The flexible single-use cryoprobes are available in various sizes. Providing broad compatibility for various clinical applications such as tissue devitalization and extraction of foreign bodies, mucous plugs, blood clots, necrotic tissue, tissue tumors (recanalization) and tissue biopsies.1

HybridKnife O-Type

1.1 mm cryoprobe

HybridKnife O-Type

1.7 mm cryoprobe

HybridKnife O-Type

2.4 mm cryoprobe

The miniaturized 1.1 mm and 1.7 mm probes enable enhanced clinical utility and compatibility.5 The 2.4 mm probe supports applications with an optimized tip design and maximum freezing performance.3

Advantages3, 4, 6, 7, 12

  • The technical performance supports consistent target tissue effects, superior reproducibility and improved standardization
  • Expanded application possibilities and compatibilities due to miniaturization
  • No reprocessing saves time and cost and reduces risk of cross-contamination
  • Enhanced shape memory
  • Patent protected slim, light and ergonomic design
  • Redesigned plug for ease of connection and disconnection

Clinical applications

with flexible single-use cryoprobes

Endobronchial cryobiopsies

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In studies, cryobiopsy is superior to forceps biopsy due to larger biopsies and no or fewer crushing artifacts. This is reflected in the diagnostic value.B3, B16

Transbronchial cryobiopsies

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For transbronchial cryobiopsies, the yield was 80 %, enabling surgical biopsies to be potentially avoided in 80 % of cases, according to the authors.B22


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Corresponding studies describe the recanalization of benign as well as malignant tumors. The rate for successful recanalizations of malignant tumors is up to 91.1 %.B2, B16


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The mean success rate for recanalization using cryodevitalization was 80 %.B11

Removal of foreign bodies, blood clots, and mucous plugs

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Cryoadhesion can be used to freeze foreign bodies, blood clots, and mucous plugs to the cryoprobe and extract them together with the bronchoscope. Sriratanaviriyakul describes successful extraction in 84.2 % of cases.B16, B26, B7, B28, B30

Medical Insights Podcast

With our free Medical Insights podcast we turn medical topics into an audible experience and will regularly provide information about trending topics. In personal interviews we talk to the experts about new applications, including the presentation of recently published studies from internationally respected scientific journals.

Flexible Cryoprobes

The 1.1 mm cryoprobe with oversheath

No removal of the bronchoscope necessary


  • Extraction of the biopsy through the working channel of the bronchoscope
  • Permanent visual control of the target area
  • Shorter reaction times in complication management (e.g. bleeding)4

Miniaturization for extended clinical utility

The cryoprobe with oversheath is our latest technology extension – measuring 1.1 mm, the thinnest cryoprobe in our portfolio. This extends compatibility and clinical utility, or example, with navigation catheters and bronchoscopes with a 1.2 mm working channel.4


The atraumatic oversheath supports a quick and easy retrieval of the biopsy through the bronchoscope. It protects the biopsy and supports a high quality of the specimen. Furthermore, it protects the bronchoscope against the thermal influence of the cryoprobes and the mechanical pressure of the frozen biopsies.4, 9, 10

Easy application

The multiadapter is used to secure the oversheath and enables easy connection to standard bronchoscopes. It can be connected easily with the bronchoscope‘s working channel and holds a seal throughout the procedure. With the oversheath extracted, suction and the insertion of flexible instruments is always enabled by an integrated seal. Furthermore, the multiadapter allows the connection and use of conventional and Luer syringes.5, 11

ERBECRYO® 2 - focus on reproducibility

The ERBECRYO® 2 is the next generation of Erbe cryo units and was designed with a focus on improved reproducibility for state-of-the-art flexible cryo applications. Several new features support ease-of-use and enhance the technical and clinical performance.

Flexible Cryoprobes

Flow control – improved reproducibility with every probe

The optimal amount of gas which runs through a probe is important for the system‘s performance. The flow control of the ERBECRYO® 2 provides just as much gas as the probe needs to reach it‘s maximum freezing power – for every probe size. Furthermore, it saves gas and provides reproducible freezing results which supports standardization.3

Plug and operate - system communication

Once connected, the system automatically detects the size of the cryoprobe. The flow control then sets the right parameters for an optimal freezing result based on probe size. Additionally, the gas bottle and footswitch connections are actively monitored.1, 3

Timer - clinical standardization

The timer provides visual and acoustic feedback of the freezing time. This supports standardization and reproducibility as the freezing time is a highly relevant factor of cryo target tissue effect.1, 2

The pulmonology workstation

Design integration

The ERBECRYO® 2 can be combined on one cart with our electrosurgical and APC devices. This multi-modular system supports handling convenience and space-saving and facilitates multiple applications in interventional pulmonology.

The workstation:

Downloads & Links

Please download further marketing material or visit our additional marketing channels.

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Register for the brand new e-learning course on transbronchial cryobiopsy for interstitial lung diseases which covers all aspects from patient selection to histopathological assessment of your transbronchial cryobiopsy:

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